毒理试验、环境试验

Toxicity and Environment Studies

毒理 - 急性毒性 

• OECD 423 / OPPTS 870.1100 急性经口
• OECD 402 / OPPTS 870.1200 急性经皮
• OECD 402 / OPPTS 870.1300 急性吸入
• OECD 404 / OPPTS 870.2500 皮肤刺激性
• OECD 405 / OPPTS 870.2400 眼刺激
• OECD 406 / OPPTS 870.2600 皮肤致敏

毒理 - 致突变性

• OECD 471 / OPPTS 870.5100 细菌回复突变 (Ames)
• OECD 474 / OPPTS 870.5395 微核试验
• OECD 475 / OPPTS 870.5385 体内哺乳动物骨髓细胞染色体畸变试验
• OECD 473 / OPPTS 870.5375 体外哺乳动物细胞染色体畸变试验
• OECD 476 / OPPTS 870.5300 体外哺乳动物细胞基因突变试验

毒理 - 亚急性、亚慢性

• OECD 407 / OPPTS 870.3050 短期重复经口染毒(28天)毒性试验
• OECD 410 / OPPTS 870.3200 短期重复经皮染毒(28天)毒性试验
• OECD 412 短期重复吸入染毒(28天)毒性试验
• OECD 408 / OPPTS 870.3100 亚慢性毒性试验 - 经口染毒（啮齿类）
• OECD 411 / OPPTS 870.3250 亚慢性毒性试验 - 经皮染毒
• OECD 413 / OPPTS 870.3465 亚慢性毒性试验 - 吸入染毒

毒理 - 替代方法

• OECD 431 体外皮肤腐蚀 - 重建人体表皮法
• OECD 430 体外皮肤腐蚀 - 经皮电阻试验法

环境

• OECD 203 / OPPTS 850.1075 鱼类急性毒性 - 斑马鱼/孔雀鱼/鲤鱼
• OECD 201 / OPPTS 850.4500 藻类生长抑制试验
• OECD 202 / OPPTS 850.1010 溞类急性活动抑制试验
• OECD 223 / OPPTS 850.2100 鸟类急性经口毒性试验
• OECD 205 / OPPTS 850.2200 鸟类短期饲喂毒性试验
• OECD 206 / OPPTS 850.2300 鸟类繁殖毒性试验
• OECD 207 蚯蚓急性毒性试验
• OECD 213 / OPPTS 850.3030 蜜蜂急性经口
• OECD 214 / OPPTS 850.3020 蜜蜂急性接触

Toxicology - Acute

• Acute Oral toxicity
• Acute Dermal Toxicity
• Acute Inhalation Toxicity
• Acute Dermal Irritation/Corrosion
• Acute Eye Irritation/Corrosion
• Skin Sensitisation

Toxicology - Mutagen

• Bacterial Reverse Mutation Test (Ames)
• Mammalian Erythrocyte Micronucleus Test
• Mammalian Bone Marrow Chromosomal Aberration Test
• In Vitro Mammalian Chromosomal Aberration Test
• In Vitro Mammalian Cell Gene Mutation Tests

Toxicology - Subacute & Subchronic

• Repeated Dose 28-day Oral Toxicity Study in Rodents
• Repeated Dose Dermal Toxicity: 28-day Study
• Subacute Inhalation Toxicity: 28-Day Study
• Subchronic Toxicity Studies
• Subchronic Dermal Toxicity: 90-day Study
• Subchronic Inhalation Toxicity: 90-day Study

Toxicology - Alternative Methods

• In Vitro Skin Corrosion: Reconstructed human epidermis
• In Vitro Skin Corrosion: Transcutaneous Electrical Resistance

Ecotoxicology

• Fish Acute Toxicity - Zebrafish / Guppy / Carp
• Fresh water Algae Growth Inhibition Test
• Daphnia Acute Immobilization Test
• Avian Acute Oral Toxicity
• Avian Dietary toxicity
• Avian Reproduction Toxicity
• Earthwarm Acute Toxicity
• Honey Bees Acute Oral Toxicity
• Honey Bees Acute Contact toxicity